Publikationen 2006-2007

Jablonka, S., Karle, K. Sandner, B., Andreassi, C., von Au, K. and M. Sendtner. Distinct and Overlapping Alterations in Motor and Sensory Neurons in a Mouse Model of Spinal Muscular Atrophy (SMA). Hum. Mol. Genet. 15, 511-518, 2006.

Oberle, S., Schober, A., Meyer, V., Holtmann, B., Henderson, C., Sendtner, M. and K. Unsicker. Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla. J. Neurosci. 26, 26, 1823-1832, 2006.

Ito, Y., Wiese, S., Schweizer, U., Chittka, A., Rossoll, W., Bömmel, H., Watabe, K., Wegner, M.and M. Sendtner. The Role of Krox20 and Sox10 in Regulation of Ciliary Neurotrophic Factor (Cntf) Gene Expression in Schwann Cells. PNAS 16, 7871-7876, 2006.

Blak, A.A., Naserke, T., Saarimaki-Vire, J., Peltopuro, P., Giraldo-Velasquez, M., Vogt Weisenhorn, D.M., Prakash, N., Sendtner, M., Partanen, J. and W. Wurst. Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev. Biol. 303, 232-243, 2006.

Bender, F.L., Fischer, M., Funk, N., Orel, N., Rethwilm, A. and M. Sendtner. High-efficiency gene transfer into cultured embryonic motoneurons using recombinant lentiviruses. Histochem. Cell Biol. 127, 439-448, 2007.

Kasperaviciute, D., Weale, M.E., Shianna, K.V., Banks, G.T., Simpson, C.L., Hansen, V.K., Turner, M.R., Shaw, C.E., Al-Chalabi, A., Pall, H.S., Goodall, E.F., Morrison, K.E., Orrell, R.W., Beck, M., Jablonka, S., Sendtner, M., Brockington, A., Ince, P.G., Hartley, J., Nixon, H., Shaw, P.J., Schiavo, G., Wood, N.W., Goldstein, D.B., Fisher, E.M.C. Large-scale pathways-based association study in amyotrophic lateral sclerosis. Brain 130, 2292-2301, 2007.

Beck, M., Sendtner, M. and K.V. Toyka. Novel SOD1 N86K mutation is associated with a severe phenotype in familial ALS. Muscle Nerve 36, 111-114, 2007.

Aguado, T., Romero, E., Monory, K., Palazuelos, J., Sendtner, M. Marsicano, G., Lutz, B. Guzmán, M. The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis. JBC 282, 23892-23898, 2007.

Frebel, K., Wiese, S., Funk, N., Pühringer, D., Sendtner, M. Differential modulation of neurite growth by the S- and the L-forms of bag1, a co-chaperone of Hsp70. Neurodeg. Dis. 4, 261-269, 2007.

Schreiner, S., Cossais, F., Fischer, K., Scholz, K., Bösl, M.R., Holtmann, B., Sendtner,M.,Wegner, M. Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development 134, 3271-81, 2007.

Jablonka, S., Beck, M., Lechner, B.D., Mayer, C. Sendtner, M. Defective Ca²⁺-channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy. J. Cell Biol. 179, 139-149, 2007.

Wiese, S., Jablonka, S., Holtmann, B., Orel, N., Rajagopal, R., Chao, M.V., Sendtner, M. Adenosine receptor A₂A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. PNAS 104, 17210-17215, 2007.

Matzke, A., Sargsyan, V., Holtmann, B., Aramuni, G., Asan, E., Sendtner, M., Pace, G., Howells, N., Zhang, W., Ponta, H. and V. Orian-Rousseau. Haploinsufficiency of c-Met in CD44-/- mice identifies a collaboration of CD44 and c-Met in vivo. Mol. Cell Biol. 27, 8797-806, 2007.

Linker, R., Kruse, N., Israel, S., Wei, T., Seubert, S., Hombach, A., Holtmann, B., Luhder, F., Ransohoff, R.M., Sendtner, M. and R. Gold. LIF-deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation. J. Immunol. 180, 2204-13, 2007.

Lang, E.M., Schlegel, N., Reiners, K., Hofmann, G.O., Sendtner, M. and E. Asan. Single-Dose Application of CNTF and BDNF Improves Remyelination of Regenerating Nerve Fibers after C7 Ventral Root Avulsion and Replantation. J. Neurotrauma 25, 384-400, 2008.

Brors, D., Hansen, S., Mlynski, R., Volkenstein, S., Aletsee, C., Sendtner, M., Ryan, A.F. and S. Dazert. Spiral Ganglion Outgrowth and Hearing Development in p75-Deficient Mice. Audiol. Neurootol. 13, 388-395, 2008.

Poesen, K., Lambrechts, DE., Van Damme, P., Dhondt, J., Bender, F., Frank, N., Bogaert, E., Claes, B., Heylen, L., Verheyen, A., Raes, K., Tjwa, M., Eriksson, U., Shibuya, M., Nuydens, R., Van Den Bosch, L., Meert, T., D'Hooge, R., Sendtner, M., Robberecht, W. and P. Carmeliet. Novel Role for VEGF-Receptor-1 and its Ligand VEGF-B in Motor Neuron Degeneration. J. Neurosci. 28, 10451-10459, 2008.

Fischer, M., Raabe, T., Heisenberg, M. and M. Sendtner. Drosophila RSK negatively regulates Bouton Number at the Neuromuscular Junction. Dev. Neurobiol. 69, 212-220, 2009.

Chiò, A., Schymick, J.C., Restagno, G., Scholz, S.W., Lombardo, F., Lai, S.L., Mora, G., Fung, H.C., Britton, A., Arepalli, S., Gibbs, J.R., Nalls, M., Berger, S., Kwee, L.C., Oddone, E.Z., Ding, J., Crews, C., Rafferty, I., Washecka, N., Hernandez, D., Ferrucci, L., Bandinelli, S., Guralnik, J., Macciardi, F., Torri, F., Lupoli, S., Chanock, S.J., Thomas, G., Hunter, D.J., Gieger, C., Wichmann, H.E., Calvo, A., Mutani, R., Battistini, S., Giannini, F., Caponnetto, C., Mancardi, G.L., La Bella, V., Valentino, F., Monsurrò, M.R., Tedeschi, G., Marinou, K., Sabatelli, M., Conte, A., Mandrioli, J., Sola, P., Salvi, F., Bartolomei, I., Siciliano, G., Carlesi, C., Orrell, R.W., Talbot, K., Simmons, Z., Connor, J., Pioro, E.P., Dunkley, T., Stephan, D.A., Kasperaviciute, D., Fisher, E.M., Jabonka, S., Sendtner, M., Beck, M., Bruijn, L., Rothstein, J., Schmidt, S., Singleton, A., Hardy, J. and Traynor, B.J. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.Hum. Mol. Genet. 18, 1524-32, 2009.

Fischer, M., Marques Pereira, P., Holtmann, B., Simon, C.M., Hanauer, A., Heisenberg, M. and Sendtner M. P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.Mol. Cell. Neurosci. 42, 134-41, 2009.

Geis, C., Beck, M., Jablonka, S., Weishaupt, A., Toyka, K.V., Sendtner, M. and C. Sommer. Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2+)]i rise in embryonic motoneurons. Neurobiology of Disease 36, 191-199, 2009.

Trimbuch, T., Beed, P., Vogt, J., Schuchmann, S., Maier, N., Kintscher, M., Breustedt, J., Schuelke, M., Streu, N., Kieselmann, O., Brunk, I., Laube, G., Strauss, U., Battefeld, A., Wende, H., Birchmeier, C., Wiese, S., Sendtner, M., Kawabe, H., Kishimoto-Suga, M., Brose, N., Baumgart, J., Geist, B., Aoki, J., Savaskan, N.E., Bräuer. A.U., Chun, J., Ninnemann, O., Schmitz, D. and R. Nitsch. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell 138,1222-35, 2009.

Rak, K., Lechner, B.D., Schneider, C., Drexl, H., Sendtner, M. and S. Jablonka. Valproic Acid, a Drug Candidate for Spinal Muscular Atrophy, blocks Axon Growth and Excitability in Motor Neurons. Neurobiology of Disease, in press. 2009.

Strelau, J., Strzelczyk, A.P., Rusu, P. Bendner, G., Wiese, S., Diella,F., von Bartheld, C.S., Klein, R., Sendtner, M. and K. Unsicker. Progressive postnatal motoneuron loss in mice lacking GDF-15. J. Neurosci., in press 2009.